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. 2011 Sep 27;71(3):415–423. doi: 10.1136/ard.2010.143529

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Relative mitogen-activated protein kinase (MAPK) activation in relation to disease outcome and progression. A. Quantitative comparison of relative MAPK phosphorylation in the synovial tissue of patients classified according to 1987 American College of Rheumatology (ACR) criteria as undifferentiated arthritis (UA) which remained UA after 2 years (UA>>UA), and UA which was diagnosed as rheumatoid arthritis (RA) after 2 years (UA>>RA). Relative phosphorylation levels of p38, extracellular signal regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) were calculated for patients diagnosed as having UA>>UA and UA>>RA. B. Quantitative comparison of relative MAPK phosphorylation in the synovial tissue of patients classified as having RA after 2 years based on 1987 ACR criteria (upper panels) and all patients with early arthritis with persistent erosive and persistent non-erosive disease (lower panels). C. Comparison of relative MAPK phosphorylation in the synovial tissue of patients classified with RA according to 2010 ACR/EULAR criteria displaying self-limiting, persistent non-erosive and erosive disease. Erosive disease was defined by a Sharp-van der Heijde erosion score ≥1 at 2 year follow-up. Relative MAPK phosphorylation was calculated as the ratio of IOD phosphorylated protein to IOD of total protein (arbitrary units). Data are presented as boxplots, where the boxes represent the 25th to 75th percentiles, the lines within the box mark the median value, and lines outside the boxes denote the 10th and 90th percentiles. Lines connecting data sets indicate statistically significant differences between groups. *p<0.05; **p<0.01; ***p<0.005.

Relative mitogen-activated protein kinase (MAPK) activation in relation to disease outcome and progression. A. Quantitative comparison of relative MAPK phosphorylation in the synovial tissue of patients classified according to 1987 American College of Rheumatology (ACR) criteria as undifferentiated arthritis (UA) which remained UA after 2 years (UA>>UA), and UA which was diagnosed as rheumatoid arthritis (RA) after 2 years (UA>>RA). Relative phosphorylation levels of p38, extracellular signal regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) were calculated for patients diagnosed as having UA>>UA and UA>>RA. B. Quantitative comparison of relative MAPK phosphorylation in the synovial tissue of patients classified as having RA after 2 years based on 1987 ACR criteria (upper panels) and all patients with early arthritis with persistent erosive and persistent non-erosive disease (lower panels). C. Comparison of relative MAPK phosphorylation in the synovial tissue of patients classified with RA according to 2010 ACR/EULAR criteria displaying self-limiting, persistent non-erosive and erosive disease. Erosive disease was defined by a Sharp-van der Heijde erosion score ≥1 at 2 year follow-up. Relative MAPK phosphorylation was calculated as the ratio of IOD phosphorylated protein to IOD of total protein (arbitrary units). Data are presented as boxplots, where the boxes represent the 25th to 75th percentiles, the lines within the box mark the median value, and lines outside the boxes denote the 10th and 90th percentiles. Lines connecting data sets indicate statistically significant differences between groups. *p<0.05; **p<0.01; ***p<0.005.