Fig. 2.

The dose-dependent inhibition of P2Y agonists by P2Y₁ antagonist MRS2179. The P-DMR amplitudes of each agonist as a function of MRS2179 dose were plotted. (a) ATP, 2-MeSATP, ATPγS, and ADP; (b) UDP, UTP, and UTPγS. The concentration was 2, 2, 100, 10, 16, 16, and 16 μM for 2-MeSATP, ADP, UDP, UTPγS, ATPγS, ATP, and UTP, respectively. Data presented are means±SEM of triplicate wells (n=3). ADP, adenosine diphosphate; ATP, adenosine 5′-triphosphate; UDP, uridine diphosphate; UTPγS; uridine 5-thiotriphosphate.