Table 8.

Inhibition of Guanosine Triphosphate-Induced Assembly and Hypernucleation/Polymer Stabilization of Bovine Brain Tubulin by Hits from the High-Content Screen Analysis of the Library of Pharmacologically Active Compound-1280 Collection

Compound (10 μM)	Percent destabilization relative to 10 μM CHC	Percent stabilization relative to 10 μM PTX
4-Phenyl-3-furoxancarbonitrile	50.71±10.7	NP
Parthenolide	−26.41±11.7	80.6±7.9
(R)-Apomorphine HCl hydrate	−2.51±54.8	NP
(S)-Apomorphine HCl hydrate	23.81±6.8	NP
6-Nitroso-1,2-benzopyrone	42.21±44.8	NP
Bay 11–7085	64.5±27.4	NP

 Data are mean values±SD (n=3).

 NP, no polymerization; CHC, colchicines; SD, standard deviation.