Utilization of Ndk in host-microbe interface

Organism	Classification of Cell Wall	Preferred lifestyle in host cells	Proposed functional roles	Reference
Porphyromonas gingivalis	Gram -negative	Intracellular	Modulation of host purinergic signaling; attenuation of ROS production; protection against mitochondrial cell-death pathways(a)	[7]; [unpublished]
Salmonella enterica typhimurium	Gram -negative	Intracellular	Modulation of host purinergic signaling	[9]
Pseudomonas aeruginosa	Gram -negative	Extracellular	Modulation of host purinergic signaling	[3, 6]
Vibrio cholerae	Gram -negative	Extracellular	Modulation of host purinergic signaling	[5,9]
Chlamydia trachomatis	Gram -negative	Intracellular	Unknown	[67](b)
Bacillus anthracis	Gram -positive	Intracellular	Unknown; spore formation(a)	[63]
Mycobacteria spp.	Other	Intracellular	Modulation of host purinergic signaling; inhibition of phagosome maturation	[2, 53]
Leishmania amazonensis	N/A	Intracellular	Modulation of host purinergic signaling	[8]
Homo sapiens H1	N/A	N/A	Metastasis suppressor; target for oncogenic viruses	[28, 31-36]
Homo sapiens H2	N/A	N/A	Inter-membrane connections (ER); target for functional mimicry(a)	[41]
Homo sapiens H4	N/A	N/A	Inter-membrane connections (Mitochondria); target for functional mimicry(a)	[45]

^(a)Footnotes: Unpublished results leading to proposed functional roles for microbe-derived Ndk.

^(b)No known role for Ndk in Chlamydia spp. has been established, though it is present within its genome.