Fig. 4.

Network analysis to uncover relationships between actin cytoskeletal proteins and cholesterol regulating proteins. The network diagram illustrates a direct relationship between key cytoskeletal proteins such as actin (ACTB) and filamin A with cholesterol regulating proteins caveolin-1 and annexin IV (Fig. 7). In addition, many of the cytoskeletal proteins regulate transcription factors SMAD3, FOXO3A, c-abl, NCX1, and c-myc that in turn regulate the expression of cholesterol regulating proteins. Legend: Green circles, objects used to build pathway from. Red circles, objects used to build pathway to. Green arrows, positive effect. Red arrow, negative effect. Blue symbol, generic binding protein. Blue receptor symbol, generic receptor. Orange reverse arrow symbol, protein kinase. Yellow symbol, generic enzyme. Red symbol, transcription factor. Purple symbol, generic channel.