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. 2011 Oct 13;11(2):M111.013904. doi: 10.1074/mcp.M111.013904

Table II. Proteins significantly up- or down-regulated in AS compared to controls. Individual sera were IgG depleted and albumin was biochemically removed. Proteins were digested and analysed by mass spectrometry. We identified 22 proteins which were significantly regulated between AS and control using LC-Progenesis software (p < 0.05 for significance of regulation).

±log2(AS/CTRL) p value Accession [IPI] Gene Protein Expected level in acute phase
2.239 0.001 IPI00022389 CRP CRP Isoform 1 of C-reactive protein up[52]
0.799 0.005 IPI00022395 C9 C9 Complement component C9 up[52]
0.653 0.014 IPI00006543 CFHR5 CFHR5 Complement factor H-related 5 up[54]
0.465 0.016 IPI00022463 TF TF Serotransferrin down[52]
0.419 0.014 IPI00019591 CFB CFB cDNAFLI55673, highly similar to Complement factor B up[52]
0.406 0.014 IPI00022391 APCS APCS Serum amyloid P-component up[40]
0.405 0.035 IPI00550991 SERPINA3 SERPINA3 cDNAFLI35730fis up[52]
−0.310 0.047 IPI00026314 GSN GSN Isoform 1 of Gelsolin down[54]
−0.371 0.014 IPI00218732 PON1 PON1 Serum paraoxonase/arylesterase 1 down[55]
−0.374 0.041 IPI00305461 ITIH2 ITIH2 Inter-alpha (Globulin) inhibitor H2, isoform CRA_a up[52]
−0.376 0.016 IPI00027482 SERPINA6 SERPINA6 Corticosteroid-binding globulin down[56]
−0.394 0.035 IPI00292530 ITIH1 ITIH1 Inter-alpha-trypsin inhibitor heavy chain H1 up[52]
−0.441 0.036 IPI00022229 APOB APOB Apolipoprotein B-100 -
−0.483 0.015 IPI00022431 AHSG AHSG cDNA FLI55606, highly similar to Alpha-2-HS-glycoprotein down[58]
−0.524 0.035 IPI00020996 IGFALS IGFALS Insulin-like growth factor-binding protein complex acid labile subunit -
−0.531 0.008 IPI00032179 SERPINC1 SERPINC1 Antithrombin-III down[57]
−0.531 0.010 IPI00296099 THBS1 THBS1 Thrombospondin-1 -
−0.672 0.014 IPI00016381 RAB27A RAB27A Isoform Long of Ras-related protein Rab-27A -
−0.677 0.014 IPI00795528 C21orf59 C21orf59 Protein -
−0.677 0.015 IPI00022432 TTR TTR Transthyretin down[52]
−0.767 0.014 IPI00301689 PPFIBP2 PPFIBP2 Liprin-beta-2 -
−0.821 0.001 IPI00328609 SERPINA4 SERPINA4 Kallistatin down[59]