Table I. LC-MS/MS data summary.

The table lists confident identifications (number of spectra successfully matched to peptides), protein groups, and %CV of replicate analysis for each of the treatment conditions. Protein group numbers are averages of six replicates (three separate cultures and two process replicates of each) per treatment (30 nm EGF, 10 μg/ml cetuximab, 500 nm gefitinib). A 5% peptide level FDR and minimum of two distinct peptides were required for confident protein identification. A protein group is defined by a set of proteins that cannot be distinguished based on the peptide identifications. A single protein is chosen to represent each protein group.

	Proliferating	EGF stimulated	Gefitinib + EGF	Cetuximab + EGF
Confident peptide-spectrum matches	32567	36156	34105	35322
Protein groups	5203	5294	5347	5250
Protein group CV (%)	4.4	4.8	4.9	4.5