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. Author manuscript; available in PMC: 2012 Feb 11.
Published in final edited form as: J Recept Signal Transduct Res. 1999 Sep;19(5):819–833. doi: 10.3109/10799899909042875

Figure 3. Carbachol concentration-response displacement curves and Schild plot (inserts) for methoctramine’s effect on recontractions of rat bladder strips in which muscarinic receptors were alkylated by 40 nM 4-DAMP mustard in the presence of 30 nM methoctramine in-vitro.

Figure 3

The concentration of methoctramine used is shown in the legend. Each curve represents the average responses of 5–6 muscle strip preparations expressed as the percent of each individual strip’s maximal carbachol response. These maximal responses (average ± S.E.M.) in grams of tension were 2.1 ± 0.18 for control (square); 2.1 ± 0.36, 2.1 ± 0.36 and 2.2 ± 0.38 for 0.3 (circle), 1 (triangle), and 3 μM (upside down triangle) methoctramine respectively. The carbachol EC50 for the antagonist-free strips was 5.1 ± 0.34 μM. The slope of the Schild plot was significantly less than unity.