TABLE 1.
Antagonist Affinity, Carbachol EC50, and Subtype Implicated for Mediating Contractions and Recontractions of Time Control and 4-DAMP Mustard Treated Rat Bladder Strips in-vitro.
| Control Contractions | Control Recontractions | Alkylated Contractions | Alkylated Recontractions | |
|---|---|---|---|---|
| methoctramine | 6.1±0.2a | 5.9±0.2 | 5.9±0.3 | 7.1±0.2d |
| Schild Slope | 0.86±0.1a | 0.98±.1 | 0.82±0.1 | 0.6±0.1b |
| p-F-HHSid | 7.5±0.2 | 7.3±0.2 | 7.5±0.3 | 6.9±0.2 |
| Schild Slope | 1.07±0.1 | 0.92±0.1 | 0.93±0.2 | 0.75±0.3 |
| 4-DAMP | 9.1±0.2 | 9.1±0.3 | 9.3±0.1 | 8.5±0.1 |
| Schild Slope | 0.93±0.1 | 1.03±0.2 | 1.23±0.2 | 0.99±0.2 |
| Carb EC50 (μM) | 1.3±0.3 | 1.9±0.3 | 3.2±0.1c | 5.1±0.3d |
|
| ||||
| Subtype Implicated | M3 | M3 | M3 | M2, M3 |
a
from (17),
b
slope significantly different from unity.
Denotes significant difference (p<0.05) from control contraction (c) or control recontraction (d).