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. Author manuscript; available in PMC: 2012 Feb 11.
Published in final edited form as: Am J Physiol Regul Integr Comp Physiol. 2002 Sep;283(3):R663–R668. doi: 10.1152/ajpregu.00116.2002

Fig. 2.

Fig. 2

Average IC50 for inhibition of carbachol (10 μM)-induced contraction of normal (A), denervated (B), and thapsigargin-treated (C) rat urinary bladder muscle strips in the presence of methoctramine, p-F-HHSiD, and combinations of methoctramine and p-F-HHSiD along with the predicted additive inhibitory potencies of the combinations (wt:wt ratios of methoctramine:p-F-HHSiD). Data were derived from Fig. 1 and display means ± SE for doses that cause 50% inhibition (IC50) of contraction induced by 10 μM carbachol. *Significant difference (P < 0.05) between the predicted inhibitory potency based on simple additivity and the actual inhibitory potency of the combination (Student’s t-test).