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. Author manuscript; available in PMC: 2012 Feb 11.
Published in final edited form as: J Pharmacol Exp Ther. 2008 Mar 13;325(3):954–960. doi: 10.1124/jpet.108.137018

Fig. 5.

Fig. 5

The isobole of additivity (solid curve) for effect = 40% KCl maximum is shown along with path (1) representing M2-M3 occupation pairs for carbachol and path (2) representing carbachol M2-M3 occupation in presence of 30 nM atropine. The intersection of each path with the isobole gives the expected M2-M3 combination (shown with S.E. bar). The experimentally derived values are shown as □ and ○ and are not statistically significantly different from their respective intersection points, thereby indicating a simply additive interaction between the M2 and M3 receptors occupied by carbachol.