Table 1.

Geographic variations in malaria pathogenesis.

South East Asia	Africa	Ref
Low transmission in general	High transmission	[38]
Severe malaria affects all age group	Severe malaria affects mostly the children under 5 yrs of age	[39]
Multiorgan failure is common with seizures, respiratory distress, and anemia being more common in children whereas renal and hepatic failures are in adults.	Cerebral malaria, severe anemia, and respiratory distress are common	[39, 40]
Total parasite burden is associated with risk of severe malaria and deaths	This relationship is less clear as children tolerate high parasitemias without developing severe malaria.	[38]
Rosetting is not associated with severe malaria	Rosetting is associated with severe malaria	[41]
Platelet-mediated clumping is associated with severe malaria	Platelet-mediated clumping is associated with severe malaria or high parasitemia	[41]