Figure 1.

Mortality of farnesoid (-) larvae at successive developmental stages. Newly hatching 1^st instar larvae expressing an RNAi that suppresses expression of HMGCR in the larval corpora allatal cells were moved to individual small diet vials and observed regularly for survival. >99% of these 1^st instar larvae burrowed into the diet soon after transfer, and were then subsequently monitored for attainment of the indicated life stages (1-2 intramolt = lst instar larva exhibited incomplete ecdysis to the 2^nd instar; NM2 = newly molted 2^nd instar; 2-3 intramolt = 2nd instar larva exhibited incomplete ecdysis to the 3rd instar; NM3 = newly molted 3rd instar; puparium = 3^rd instar larva attained puparium formation but had not everted to white pupa; < pharate adult = had attained at least white pupa stage but not attained pharate adult status). n = 341