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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Mol Pharm. 2011 Nov 22;9(1):168–175. doi: 10.1021/mp200434n

Fig. 6. Tumoricidal effect of Prodrug 8 in MDA-MB-435 carcinoma in vivo.

Fig. 6

(A) Confocal analysis of legumain (green) and integrin αvβ3 (red) in MDA-MB-435 tumor tissue. (B) In vivo effect of Prodrug 8 on MDA-MB435 carcinoma. Starting on day 15, when the tumors averaged ≈5 mm in diameter, the MDA-MB435 tumor mice were treated with Saline alone, and Prodrug 8 (3mg/kg) on day 15, 20, 25, 30, 35 and 40; The experiment were repeated twice and 6 mice were used in each treated group; (p<0.01). (b) Kaplan-Meier survival curves of mice bearing MDA-MB435 tumors in Control and Prodrug 8 groups. The survival was based on the primary tumor diameter (>1.5 cm) and natural death.