Table 2.
Outcomes dichotomized by t-PA dose
| P value | χ2 | T-PA ≤ 50 mg | t-PA >50 mg | Total | |
|---|---|---|---|---|---|
| N | 39 | 28 | 67 | ||
| Reperfusion ≥ 50% | 0.564† | 0.332 | 25 (64%) | 16 (57%) | 41 (61%) |
| Complete reperfusion | 0.464† | 0.496 | 20 (51%) | 12 (43%) | 32 (48%) |
| Median hemorrhage volume (ml)* | 0.120 § | 2.41 | 7.6 (2.0-37) | 22 (7.8-114) | 8.8 (4.5-49.9) |
| Presence of hemorrhage | 0.258 >† | 1.28 | 9 (23%) | 8 (36%) | 19 (28%) |
| Symptomatic hemorrhage | 0.306 † | 4.68 | 1 (2.6%) | 5 (18%) | 6 (9.1%) |
| Hemorrhage >25 ml | 0.206† | 1.60 | 3 (7.7%) | 5 (18%) | 8 (12%) |
| Infarct volume (ml) | 0.689§ | 0.160 | 44 (12-109) | 47 (11-147) | 47 (11-134) |
| Modified Rankin ≤2 | 0.756† | 0.097 | 21 (54%) | 14 (50%) | 35 (52%) |
| ΔNIHSS by discharge | 0.541§ | 0.373 | -8.0 (-11 − +2.0) | -5.0 (-12 − +3.5) | - 7.0 (-11 − 0) |
| ΔNIHSS by 24 hours | 0.449§ | 0.574 | -5.0 (-10 − 0) | -3.5 (-10 − +2.0) | -4.0 (-10- +1.0) |
| Death during hospitalization | 0.326† | 0.568 | 5 (13%) | 5 (18%) | 10 (15%) |
| Death by 3 months | 0.664† | 0.189 | 8 (20%) | 7 (25%) | 15 (22%) |
| *in patients who hemorrhaged (n=18); 25-75% quartiles presented in parentheses for continuous data and percentages presented in parentheses for nominal/ordinal data. ΔNIHSS scores were treated as continuous data. §Wilcoxon Rank Sums 1-way test (continuous variables); †Pearson χ2 (nominal/ordinal variables); Bonferroni correction for multiple tests requires p < .005 for significance. ΔNIHSS = change in NIHSS. | |||||