Figure 2.

CyPPA inhibits evoked spike trains and prolongates the post train afterhyperpolarizations (ptAHP) in midbrain slices from mice. (A) Representative spike trains evoked by a 200 ms, 0.5 nA current injection under control conditions (left), after 10 μM CyPPA (middle), and with co-application of 300 nM apamin (right). The dotted line indicates the V_m (−56 mV) prior to first control current injection. (B) Overlays highlighting the prolongation of the ptAHP by CyPPA, and the presence of a slow apamin insensitive component.