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. 2012 Feb 13;3:11. doi: 10.3389/fphar.2012.00011

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Copyright © 2012 Herrik, Redrobe, Holst, Hougaard, Sandager-Nielsen, Nielsen, Ji, Holst, Rasmussen, Nielsen, Strøbæk, Shepard and Christophersen.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

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CyPPA reverses the effect of the negative SK channel modulator, NS8593, on the spontaneous activity of rat SNc neurons in midbrain slices. Pacemaker-like AP firing recorded under control conditions (upper panel) is changed into bursting upon application of 10 μM NS8593 (middle panel). Note the progressive decrease in spike amplitude during the plateau phase and the sudden hyperpolarizations separating the bursts. Co-application of CyPPA (10 μM) decreases the number of spikes, reduces the duration of the plateau and increases the precision of action potential firing.