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. 2012 Feb 13;3:11. doi: 10.3389/fphar.2012.00011

Figure 6.

Figure 6

CyPPA depresses explorative activity and methylphenidate-induced hyperactivity in mice. (A) Effect of CyPPA on basic explorative activity. Data are expressed as mean total distances traveled + SEM. Mice were injected with vehicle (i.p.; open bar) or CyPPA (3, 10, and 30 mg/kg, blue bars) 15 min before testing. ***P < 0.001 versus vehicle treated group (two-way ANOVA followed by Tukey’s multiple comparison test, n = 7). (B) Effects of CyPPA on methylphenidate (METH)-induced hyperactivity. Data are expressed as mean total distances traveled + SEM. Mice were dosed (i.p.) with vehicle (open bar) or CyPPA (3, 10, and 30 mg/kg) 15 min before administration of METH (2.5 mg/kg, s.c.) or saline, respectively (blue bars). ###P < 0.001 versus vehicle treated group, ***P < 0.001 versus METH treated group (two-way ANOVA followed by Tukey’s multiple comparison test, n = 7).