Figure 7.

CyPPA counteracts methylphenidate-induced stereotypies in mice. Effects of CyPPA on methylphenidate (METH)-induced stereotypy. Data are expressed as mean total gnawing score + SEM. Mice were dosed (i.p.) with vehicle or CyPPA (3, 10, and 30 mg/kg) 15 min before administration of METH (40 mg/kg, s.c.) or saline, respectively (blue bars). ^###P < 0.001 versus vehicle treated group, ^#P < 0.05, ***P < 0.001 versus METH treated group (one-way ANOVA followed by Tukey’s multiple comparison test, n = 6).