Table 13.

—[Section 3.4.3] Summary of Findings: Should Any Heparin (LDUH, LMWH) vs Placebo Be Used for DVT Prophylaxis in Critically Ill Adult Patients?^12,70,71

Outcome	No. of Participants (Studies) Follow-up	Quality of the Evidence (GRADE)	Relative Effect (95% CI)	Anticipated Absolute Effects
				Baseline Risk	Risk Difference With Any Heparin (95% CI)
Symptomatic DVT	1,935 (1 RCT) 5-28 d	Moderate due to serious imprecisiona	RR, 0.86 (0.59-1.25)	58 per 1,000	4 fewer per 1,000 (from 12 fewer to 8 more)
Pulmonary embolus	1,935 (1 RCT) 5-28 d	Low due to serious imprecisiona and indirectnessb	RR, 0.73 (0.26-2.11)	42 per 1,000	11 fewer per 1,000 (from 31 fewer to 47 more)
Death	169 (1 RCT) 5-28 d	Low due to very serious imprecisiona	RR, 1.01 (0.40-2.57)	94 per 1,000	1 more per 1,000 (from 56 fewer to 148 more)
Major bleeding	221 (1 RCT) 5-28 d	Low due to very serious imprecisiona	RR, 2.09 (0.54-8.16)	27 per 1,000	29 more per 1,000 (from 12 fewer to 190 more)

See Table 1 and 4 legends for expansion of abbreviations.

^aWe will consider the presence of serious imprecision when there are <300 events in total (events in treatment and control patients) or when CIs include appreciable harms and benefits.

^bRR estimated from a mix of symptomatic and asymptomatic events.