Table 13.

—[Section 6.1] UFH: Weight-Based Nomogram Compared With Fixed Initial Dose for Patients With Thromboembolic Disease^149,150,152

Outcomes	No. of Participants (Studies), Follow-up	Quality of the Evidence (GRADE)	Relative Effect (95% CI)	Anticipated Absolute Effectsa
				Risk With Fixed Initial Dose	Risk Difference With UFH-Weight-Based Nomogram (95% CI)
Thromboembolism	292 (3 studies), 2-90 db	Lowc,d due to risk of bias and imprecision	OR 0.22 (0.02-1.13)e	57 per 1,000f	44 fewer per 1,000 (from 56 fewer to 7 more)
Major hemorrhage	179 (2 studiesg), 1 wk	Very lowc,d due to risk of bias and imprecision	Not estimableh	11 per 1,000	10 fewer per 1,000 (from 30 fewer to 10 more)

See Table 1 and 2 legends for expansion of abbreviations.

^aTime frame is days to weeks.

^bOnly Raschke et al¹⁵² collected data over a 3-mo period.

^cThe studies did not use blinding.

^dNone of the studies was powered for clinical outcomes, which were few and poorly reported with regard to type and timing.

^eFisher exact test.

^fTwo of the eight events occurred after discontinuation of warfarin.

^gBecker et al¹⁴⁹ reported 2% bleeding without specifying allocation group or type of bleeding.

^hZero events in control group; 95% CI on OR not estimable.