Table 1.

—Structured Clinical Questions

Rec.	Table	S-Tablea	Population	Intervention(s)	Comparator	Outcome	Method
Ischemic stroke: acute management
2.1.1	2, 3, 4	1, 2, 3, 4	Patients with acute ischemic stroke	IV r-tPA	No IV r-tPA	Mortality, good functional outcome	R
2.1.2
2.1.3
2.2.1	5	5, 6	Patients with acute ischemic stroke	Intraarterial r-tPA	No IA r-tPA	Same as above	R
2.2.2	6	5, 7	Patients with acute ischemic stroke	Intraarterial+IV r-tPA	IV r-tPA	Same as above	C
2.3		8, 9, 10	Patients with acute ischemic stroke	Mechanical thrombectomy	No mechanical thrombectomy	Same as above	C
2.4	7	11, 12	Patients with acute ischemic stroke or TIA	Aspirin	No aspirin	Mortality, good functional outcome, nonfatal major extracranial bleed	R
2.5	8	13, 14	Patients with acute ischemic stroke or TIA	Therapeutic anticoagulation	Aspirin	Same as above	R
VTE prevention in stroke patients
3.1.1	9	15, 16	Patients with acute ischemic stroke and restricted mobility	Prophylactic-dose heparin	No prophylactic-dose heparin	Mortality, PE, symptomatic DVT, symptomatic intracranial hemorrhage, major extracranial hemorrhage	R
3.1.2	10	15, 17	Patients with acute stroke (ischemic or hemorrhagic) and restricted mobility	Prophylactic-dose unfractionated heparin	Prophylactic-dose LMWH	Same as above	R
3.2.2
3.1.1	11	15, 18	Patients with acute stroke (ischemic or hemorrhagic) and restricted mobility	Intermittent pneumatic compression stockings	No intermittent pneumatic compression stockings	Mortality, PE, symptomatic DVT	R
3.2.1
3.1.3	12	15, 19	Patients with acute stroke (ischemic or hemorrhagic) and restricted mobility	Elastic compression stockings	No elastic compression stockings	Mortality, PE, symptomatic DVT, skin complications	R
3.2.3
3.2.1	13	15, 20	Patients with primary ICH and restricted mobility	Prophylactic-dose heparin	No prophylactic-dose heparin	Mortality, PE, symptomatic DVT, rebleeding	R
3.2.1	14	15, 21	Patients with primary ICH and restricted mobility	Early (day 2) prophylactic-dose heparin	Late (day 4) prophylactic-dose heparin	Same as above	R
Secondary stroke prevention
4.1.1	15	22, 23	Patients with a history of noncardioembolic ischemic stroke or TIA	Aspirin	No aspirin	Mortality, nonfatal recurrent stroke, nonfatal MI, nonfatal major extracranial bleeding	R
4.1.1	16	22, 24	Patients with a history of noncardioembolic ischemic stroke or TIA	Clopidogrel	Aspirin	Same as above	R
4.1.2
4.1.1	17	22, 25	Patients with a history of noncardioembolic ischemic stroke or TIA	Aspirin plus dipyridamole	Aspirin	Same as above	R
4.1.2
4.1.1	18	22, 26	Patients with a history of noncardioembolic ischemic stroke or TIA	Aspirin plus dipyridamole	Clopidogrel	Same as above	R
4.1.2
4.1.1	19	22, 27	Patients with a history of noncardioembolic ischemic stroke or TIA	Aspirin plus clopidogrel	Clopidogrel	Same as above	R
4.1.1	20	22, 28	Patients with a history of noncardioembolic ischemic stroke or TIA	Cilostazol	Aspirin	Same as above	R
4.1.2
4.1.1	21	22, 29	Patients with a history of noncardioembolic ischemic stroke or TIA	Triflusal	Aspirin	Same as above	R
4.1.1	22	30, 31	Patients with a history of noncardioembolic ischemic stroke or TIA	Oral anticoagulation	Aspirin	Same as above	R
4.2.1	23		Patients with AF and a history of stroke or TIA	Oral anticoagulation	No Oral anticoagulation	Same as above	R
4.2.2	See You et al3		Patients with AF and a history of stroke or TIA	Dabigatran	No antiplatelets	Same as above	R
4.2.3			Patients with AF and a history of stroke or TIA	Aspirin and clopidogrel	Aspirin	Same as above	R
4.3			Patients with a history of a primary ICH and an indication for Coumadin for ischemic stroke prevention	Antithrombotic therapy	No antithrombotic therapy	QALY	D
Cerebral venous sinus thrombosis
5.1	24	32, 33	Patients with cerebral venous sinus thrombosis	Therapeutic anticoagulation	No therapeutic anticoagulation	Mortality, good functional outcome, nonfatal major bleeding	R

AF=atrial fibrillation; C=cohort study; D=decision model; ICH=intracerebral hemorrhage; MI=myocardial infarction; PE=pulmonary embolism; QALY=quality-adjusted life-year; Rec.=recommendation; R=randomized controlled trial; r-tPA=recombinant tissue plasminogen activator; TIA=transient ischemic attack.

^aSee supplemental tables in the online supplement.