Skip to main content
. Author manuscript; available in PMC: 2012 Feb 13.
Published in final edited form as: Eur J Nucl Med Mol Imaging. 2010 Oct 9;38(2):334–342. doi: 10.1007/s00259-010-1633-8

Table 1.

Values of optimization criteria at each dosage and affinity. Light grey represents AUC[CIAR] >10,000 rad and therapeutic ratio >10. Medium grey represents 10,000 rad >AUC[CIAR] >5,000 rad and therapeutic ratio >10. Black represents 5,000 rad >AUC[CIAR] >2,500 rad

a. AUC[CIAR] in units of Gy at each doage and affinity
Radiation of Bound Antibody (in unit of Gy)
Kd (× 10−8) 1.00 0.80 0.60 0.40 0.20 0.10 0.08 0.06 0.04 0.02 0.01
Dosage(mg)
0.2 3.81 4.66 6.04 8.64 15.72 27.85 33.15 41.09 54.18 79.95 106.22
0.4 6.81 8.21 10.41 14.43 24.73 41.13 48.01 58.06 74.17 104.74 134.92
0.6 9.21 10.95 13.63 18.38 29.89 47.19 54.22 64.33 80.29 110.05 139.13
0.8 11.16 13.13 16.09 21.2 33.14 50.52 57.51 67.52 83.26 112.54 141.12
1 12.78 14.89 18.02 23.31 35.41 52.74 59.68 69.61 85.2 114.18 142.44
1.2 14.16 16.36 19.59 24.98 37.13 54.4 61.29 71.16 86.65 115.4 143.42
1.4 15.34 17.61 20.9 26.35 38.51 55.71 62.58 72.39 87.79 116.37 144.2
1.6 16.37 18.69 22.02 27.51 39.66 56.8 63.64 73.41 88.74 117.18 144.86
1.8 17.29 19.64 23 28.5 40.64 57.73 64.55 74.28 89.56 117.86 145.41
2 18.11 20.48 23.87 29.38 41.5 58.55 65.37 75.05 90.27 118.47 145.9
2.2 18.86 21.24 24.64 30.16 42.26 59.27 66.04 75.72 90.9 119 146.33
2.4 19.53 21.93 25.34 30.86 42.95 59.91 66.67 76.33 91.46 119.48 146.72
2.6 20.15 22.56 25.98 31.5 43.57 60.5 67.24 76.88 91.97 119.91 147.07
2.8 2.073 23.15 26.56 32.08 44.14 61.04 67.77 77.38 92.44 120.31 147.39
3 21.26 23.68 27.11 32.62 44.66 61.53 68.25 77.84 92.87 120.68 147.68
3.2 21.76 24.19 27.16 33.12 45.15 61.99 68.69 78.27 93.27 121.02 147.96
3.4 22.22 24.66 28.08 33.59 45.6 62.41 69.11 78.67 93.64 121.33 148.21
3.6 22.66 25.1 28.52 34.03 46.02 62.81 69.5 79.04 93.99 121.63 148.45
3.8 23.07 25.51 28.94 34.44 46.62 63.19 69.86 79.4 94.32 121.91 148.67
4 23.47 25.9 29.33 34.83 46.79 63.54 70.21 79.73 94.63 122.17 148.89
b. Therapeutic ratio at each dosage and affinity
Therapeutic Ratio
Kd (× 10−8) 1.00 0.80 0.60 0.40 0.20 0.10 0.08 0.06 0.04 0.02 0.01
Dosage(mg)
0.2 10 13 16 23 43 91 114 153 233 322 91
0.4 9 11 14 19 33 66 80 103 148 195 66
0.6 8 10 12 16 27 49 58 73 102 131 49
0.8 7 9 11 14 22 39 46 57 77 98 39
1 7 8 10 13 19 32 38 46 62 79 32
1.2 6 7 9 11 17 28 32 39 52 66 28
1.4 6 7 8 10 15 24 28 34 45 56 24
1.6 5 6 7 9 13 21 25 30 40 49 21
1.8 5 6 7 8 12 19 22 27 35 44 19
2 5 5 6 8 11 18 20 24 32 40 18
2.2 5 5 6 7 10 16 19 22 29 36 16
2.4 4 5 6 7 10 15 17 21 27 33 15
2.6 4 5 5 6 9 14 16 19 25 31 14
2.8 4 4 5 6 8 13 15 18 23 38 13
3 4 4 5 6 8 12 14 17 22 27 12
3.2 4 4 5 6 8 12 13 16 20 25 12
3.4 3 4 4 5 7 11 12 15 19 24 11
3.6 3 4 4 5 7 10 12 14 18 22 10
3.8 3 4 4 5 7 10 11 13 17 21 10
4 3 3 4 5 6 9 11 13 16 20 9