Table 1.
Values of optimization criteria at each dosage and affinity. Light grey represents AUC[CIAR] >10,000 rad and therapeutic ratio >10. Medium grey represents 10,000 rad >AUC[CIAR] >5,000 rad and therapeutic ratio >10. Black represents 5,000 rad >AUC[CIAR] >2,500 rad
| a. AUC[CIAR] in units of Gy at each doage and affinity | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Radiation of Bound Antibody (in unit of Gy) | |||||||||||
| Kd (× 10−8) | 1.00 | 0.80 | 0.60 | 0.40 | 0.20 | 0.10 | 0.08 | 0.06 | 0.04 | 0.02 | 0.01 |
| Dosage(mg) | |||||||||||
| 0.2 | 3.81 | 4.66 | 6.04 | 8.64 | 15.72 | 27.85 | 33.15 | 41.09 | 54.18 | 79.95 | 106.22 |
| 0.4 | 6.81 | 8.21 | 10.41 | 14.43 | 24.73 | 41.13 | 48.01 | 58.06 | 74.17 | 104.74 | 134.92 |
| 0.6 | 9.21 | 10.95 | 13.63 | 18.38 | 29.89 | 47.19 | 54.22 | 64.33 | 80.29 | 110.05 | 139.13 |
| 0.8 | 11.16 | 13.13 | 16.09 | 21.2 | 33.14 | 50.52 | 57.51 | 67.52 | 83.26 | 112.54 | 141.12 |
| 1 | 12.78 | 14.89 | 18.02 | 23.31 | 35.41 | 52.74 | 59.68 | 69.61 | 85.2 | 114.18 | 142.44 |
| 1.2 | 14.16 | 16.36 | 19.59 | 24.98 | 37.13 | 54.4 | 61.29 | 71.16 | 86.65 | 115.4 | 143.42 |
| 1.4 | 15.34 | 17.61 | 20.9 | 26.35 | 38.51 | 55.71 | 62.58 | 72.39 | 87.79 | 116.37 | 144.2 |
| 1.6 | 16.37 | 18.69 | 22.02 | 27.51 | 39.66 | 56.8 | 63.64 | 73.41 | 88.74 | 117.18 | 144.86 |
| 1.8 | 17.29 | 19.64 | 23 | 28.5 | 40.64 | 57.73 | 64.55 | 74.28 | 89.56 | 117.86 | 145.41 |
| 2 | 18.11 | 20.48 | 23.87 | 29.38 | 41.5 | 58.55 | 65.37 | 75.05 | 90.27 | 118.47 | 145.9 |
| 2.2 | 18.86 | 21.24 | 24.64 | 30.16 | 42.26 | 59.27 | 66.04 | 75.72 | 90.9 | 119 | 146.33 |
| 2.4 | 19.53 | 21.93 | 25.34 | 30.86 | 42.95 | 59.91 | 66.67 | 76.33 | 91.46 | 119.48 | 146.72 |
| 2.6 | 20.15 | 22.56 | 25.98 | 31.5 | 43.57 | 60.5 | 67.24 | 76.88 | 91.97 | 119.91 | 147.07 |
| 2.8 | 2.073 | 23.15 | 26.56 | 32.08 | 44.14 | 61.04 | 67.77 | 77.38 | 92.44 | 120.31 | 147.39 |
| 3 | 21.26 | 23.68 | 27.11 | 32.62 | 44.66 | 61.53 | 68.25 | 77.84 | 92.87 | 120.68 | 147.68 |
| 3.2 | 21.76 | 24.19 | 27.16 | 33.12 | 45.15 | 61.99 | 68.69 | 78.27 | 93.27 | 121.02 | 147.96 |
| 3.4 | 22.22 | 24.66 | 28.08 | 33.59 | 45.6 | 62.41 | 69.11 | 78.67 | 93.64 | 121.33 | 148.21 |
| 3.6 | 22.66 | 25.1 | 28.52 | 34.03 | 46.02 | 62.81 | 69.5 | 79.04 | 93.99 | 121.63 | 148.45 |
| 3.8 | 23.07 | 25.51 | 28.94 | 34.44 | 46.62 | 63.19 | 69.86 | 79.4 | 94.32 | 121.91 | 148.67 |
| 4 | 23.47 | 25.9 | 29.33 | 34.83 | 46.79 | 63.54 | 70.21 | 79.73 | 94.63 | 122.17 | 148.89 |
| b. Therapeutic ratio at each dosage and affinity | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Therapeutic Ratio | |||||||||||
| Kd (× 10−8) | 1.00 | 0.80 | 0.60 | 0.40 | 0.20 | 0.10 | 0.08 | 0.06 | 0.04 | 0.02 | 0.01 |
| Dosage(mg) | |||||||||||
| 0.2 | 10 | 13 | 16 | 23 | 43 | 91 | 114 | 153 | 233 | 322 | 91 |
| 0.4 | 9 | 11 | 14 | 19 | 33 | 66 | 80 | 103 | 148 | 195 | 66 |
| 0.6 | 8 | 10 | 12 | 16 | 27 | 49 | 58 | 73 | 102 | 131 | 49 |
| 0.8 | 7 | 9 | 11 | 14 | 22 | 39 | 46 | 57 | 77 | 98 | 39 |
| 1 | 7 | 8 | 10 | 13 | 19 | 32 | 38 | 46 | 62 | 79 | 32 |
| 1.2 | 6 | 7 | 9 | 11 | 17 | 28 | 32 | 39 | 52 | 66 | 28 |
| 1.4 | 6 | 7 | 8 | 10 | 15 | 24 | 28 | 34 | 45 | 56 | 24 |
| 1.6 | 5 | 6 | 7 | 9 | 13 | 21 | 25 | 30 | 40 | 49 | 21 |
| 1.8 | 5 | 6 | 7 | 8 | 12 | 19 | 22 | 27 | 35 | 44 | 19 |
| 2 | 5 | 5 | 6 | 8 | 11 | 18 | 20 | 24 | 32 | 40 | 18 |
| 2.2 | 5 | 5 | 6 | 7 | 10 | 16 | 19 | 22 | 29 | 36 | 16 |
| 2.4 | 4 | 5 | 6 | 7 | 10 | 15 | 17 | 21 | 27 | 33 | 15 |
| 2.6 | 4 | 5 | 5 | 6 | 9 | 14 | 16 | 19 | 25 | 31 | 14 |
| 2.8 | 4 | 4 | 5 | 6 | 8 | 13 | 15 | 18 | 23 | 38 | 13 |
| 3 | 4 | 4 | 5 | 6 | 8 | 12 | 14 | 17 | 22 | 27 | 12 |
| 3.2 | 4 | 4 | 5 | 6 | 8 | 12 | 13 | 16 | 20 | 25 | 12 |
| 3.4 | 3 | 4 | 4 | 5 | 7 | 11 | 12 | 15 | 19 | 24 | 11 |
| 3.6 | 3 | 4 | 4 | 5 | 7 | 10 | 12 | 14 | 18 | 22 | 10 |
| 3.8 | 3 | 4 | 4 | 5 | 7 | 10 | 11 | 13 | 17 | 21 | 10 |
| 4 | 3 | 3 | 4 | 5 | 6 | 9 | 11 | 13 | 16 | 20 | 9 |