Figure 5. Adoptive transfer of ex vivo propagated T cells after CHOP improves survival of canines with NHL.

Differences between 12 historical stage-, age-, and size-matched controls treated with CHOP (red dashed line) and 7 (curve A) or 8 (curve B) research participants treated with CHOP and T cells (blue solid line) over 500 days in evaluating (a) tumor-free survival measured after achieving CR (p = 0.005) and (b) overall survival measured upon diagnosis of NHL diagnosis (p = 0.03). One dog (P42) had progressive disease at the time of T-cell infusions and was not evaluated in the tumor-free survival analysis, but was included in the overall survival analysis. This patient had stable disease for 112 days after study day 14.