Skip to main content
. 2012 Jan;37(1):32–38.

Table 2.

Assessment of Pharmacotherapeutic Interventions for Post-traumatic Stress Disorder in War Veterans

Significant Benefit Some Benefit Unknown Benefit No Benefit

  • SSRIs

  • SNRIs

  • MAO inhibitors (phenelzine) [caution*]

  • Mirtazapine

  • Nefazodone [caution*]

  • Prazosin (for sleep/nightmares)

  • TCAs

  • Atypical antipsychotics (monotherapy)

  • Atypical antipsychotics (adjunctive)

  • Bupropion

  • Buspirone

  • Clonidine

  • Conventional antipsychotics

  • Gabapentin

  • Lamotrigine

  • Non-benzodiazepine hypnotics

  • Prazosin (for global PTSD)

  • Propranolol

  • Trazodone (adjunctive)

  • Benzodiazepines [harmful]

  • Guanfacine

  • Risperidone

  • Tiagabine

  • Topiramate

  • Valproate
*

Attention to drug-drug and dietary interactions.

MAO = monoamine oxidase; SSRI = selective serotonin reuptake inhibitor; SNRI = serotonin–norepinephrine reuptake inhibitor; TCA = tricyclic antidepressant.

Adapted from the Department of Veterans Affairs and the Department of Defense.52