Table 2.

Maximum Restarting Doses After a Safety Interruption^*

Current Platelet Count	Maximum Dose When Restarting Treatment*
Greater than or equal to 125 x 109/L	20 mg twice daily
100 to less than 125 x 109/L	15 mg twice daily
75 to less than 100 x 109/L	10 mg twice daily for at least 2 weeks; if stable, may increase to 15 mg twice daily
50 to less than 75 x 109/L	5 mg twice daily for at least 2 weeks; if stable, may increase to 10 mg twice daily
Below 50 x 109/L	Continue hold

^*Maximum doses are displayed. When restarting, begin with a dose at least 5 mg twice daily below the dose at interruption.

From Jakafi prescribing information.