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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Circ Cardiovasc Genet. 2011 Oct 18;4(6):681–686. doi: 10.1161/CIRCGENETICS.111.960682

Table 1.

Summary of participating studies for the meta-analysis

Participating studies Subjects Age (years)* Female (%) Assay SNP Number of subjects
Sample Method Intra assay CV Inter assay CV A/A genotype A/a genotype a/a genotype Total
sICAM-1 Bruneck17 Population-based 63±11 51.1 Plasma ELISA 5.1% 6.9% rs579459 440 268 33 741
FHS12 Community-based 49±14 45.9 Serum ELISA 3.9% 3.9% rs579459 4,176 2,340 329 6,845
ARIC12 Community-based 56±5 38.4 Plasma ELISA 4.0% 5.1% rs579459 495 287 43 825
RS12 Community-based 70±9 53.3 Plasma ELISA 6.9% rs579459 351 214 35 600
CHS12 Population-based 73±6 42.8 Plasma ELISA 5.0% rs579459 855 556 69 1,480
WGHS11 Population-based 55±7 100 Plasma ELISA 6.7% rs507666† 14,391 6,857 936 22,184
NHS14 Type 2 diabetes 56±7 100 Plasma ELISA 3.3–4.8% rs651007‡ 612 337 47 996
sP-selectin Bruneck17 Population-based 63±11 51.1 Plasma ELISA 5.5% 6.9% rs579459 440 268 33 741
FHS12 Community-based 61±10 45.6 Plasma ELISA 3.2% rs579459 1,872 1,000 164 3,036
ARIC12 Community-based 57±5 35.7 Plasma ELISA 3.9% 5.8% rs579459 432 265 41 738
RS12 Community-based 69±9 48.8 Plasma ELISA <5% <10% rs579459 253 135 18 406
sE-selectin Bruneck17 Population-based 63±11 51.1 Plasma ELISA 4.8% 7.4% rs579459 440 268 33 741
DCCT/EDIC13 Type 1 diabetes 39±7 46 Serum SLPA <2% 5% rs579459 452 209 24 685
DCCT siblings13 Non-diabetics 45±9 57 Serum SLPA <2% 5% rs579459 280 143 15 438
NHS14 Type 2 diabetes 56±7 100 Plasma ELISA 4.5–6.2% rs651007‡ 612 337 47 996

All participants were of European ancestry. FHS, Framingham Heart Study; ARIC, Atherosclerosis Risk in Communities; RS, Rotterdam Study; CHS, Cardiovascular Health Study; WGHS, Women’s Genome Health Study; NHS, Nurses’ Health Study; DCCT, Diabetes Control and Complications Trial; EDIC, Epidemiology of Diabetes Intervention and Complications.

Genotype distributions in the various cohorts were all consistent with Hardy-Weinberg equilibrium except for WGHS (sICAM-1, p=0.001) and FHS (sP-selectin, p=0.046). SNP, single nucleotide polymorphism; A/A genotype, major allele homozygotes; A/a genotype, heterozygotes; a/a genotype, minor allele homozygotes; CV, coefficient of variation; ELISA, Enzyme-linked immunosorbent assay; SLPA; SearchLight™ Proteome Array.

*

mean ± standard deviation.

†

in nearly complete linkage disequilibrium with SNP rs579459 (r2 = 0.96) based on data from the 1000 Genomes Project;

‡

in complete linkage disequilibrium with SNP rs579459 (r2 = 1) based on data from the 1000 Genomes Project