. Author manuscript; available in PMC: 2012 Feb 13.

Published in final edited form as: Curr Med Chem. 2011;18(25):3853–3870. doi: 10.2174/092986711803414331

Table 2.

Antitumor and Cytotoxicity Activity of Diazapodophyllotoxin Analogues 69–73

Compds	Antitumor activity against P-388 leukemia T/C (%) @ different doses (mg/kg/injection)^a							Cytotoxicity L1210 IC₅₀ (μg/mL)
Compds	2.5	5	10	25	50	100	250	Cytotoxicity L1210 IC₅₀ (μg/mL)
1	111		109	111	<85			0.0036
69a		117	144	161	239			0.42
69b			123	137	159	214		0.22
69c		119	131	153	165	233	<85	0.052
69d		117	133	150	172	94	<85	0.080
70a	111	124	128	150	161	172	>326	0.050
70b			110	139	156	206	206	0.16
70c		139	144	156	177	<85		0.055
70d		114	131	147	199	<85		0.028
71			111	122	147	147	161	0.75
72		104	109	114	134	153	<85	0.090
73		104	109	109	111	109	144	0.54

single i.p. treatment on day 1. T/C, median survival time of test animals/median survival time of control animals; 125% or above considered active; <85% considered toxic.