Table 5.

Antiproliferative Activities of Dihydropyridopyrazoles 78–110

Compd				% cell viability			% apoptosis Jurkat
				HeLa	MCF-7/AZ	Jurkat
	R1	R2	R
1				19 ± 5	55 ± 3	18 ± 5	54 ± 2
2				91 ± 2	76 ± 2	75 ± 5	4 ± 3
76a				53 ± 5	58 ± 4	35 ± 6	49 ± 4
76c				54 ± 6	52 ± 3	54 ± 1	55 ± 4
78	Ph	4-Br-Ph	3,4,5-tri-OMe-Ph	73 ± 5	90 ± 3	99 ± 1	2 ± 1
79	4-Me-Ph	Me	3,4,5-tri-OMe-Ph	77 ± 4	71 ± 5	77 ± 2	23 ± 1
80	H	4-Br-Ph	3,4,5-tri-OMe-Ph	67 ± 4	98 ± 3	78 ± 7	5 ± 1
81	iPr	Me	3,4,5-tri-OMe-Ph	83 ± 5	99 ± 0	77 ± 9	4 ± 0
82	Me	Me	3,4,5-tri-OMe-Ph	55 ± 3	98 ± 1	79 ± 4	5 ± 1
83	H	Me	3,4,5-tri-OMe-Ph	50 ± 2	58 ± 5	47 ± 3	55 ± 4
84	H	Me	3,4-di-OMe-Ph	73 ± 3	95 ± 4	88 ± 2	5 ± 1
85	H	Me	4-OMe-Ph	73 ± 7	82 ± 3	94 ± 4	11 ± 1
86	H	Me	4-OCF3-Ph	97 ± 2	84 ± 3	97 ± 6	9 ± 2
87	H	Me	4-SMe-Ph	45 ± 2	95 ± 4	87 ± 4	14 ± 6
88	H	Me	Ph	74 ± 4	84 ± 3	87 ± 5	10 ± 2
89	H	Me	2-NO2-Ph	71 ± 4	99 ± 2	64 ± 1	6 ± 1
90	H	Me	4-OH-3-OMe-5-NO2-Ph	78 ± 3	89 ± 5	90 ± 2	2 ± 1
91	H	Me	3-Br-Ph	51 ± 3	63 ± 4	68 ± 3	58 ± 2
92	H	Me	3,5-di-Br-4-OH-Ph	58 ± 7	60 ± 4	58 ± 3	53 ± 0
93	H	Me	3-Br-4-OEt-5-OMe-Ph	52 ± 2	49 ± 4	28 ± 5	49 ± 1
94	H	Me	4-OAc-3-Br-5-OMe-Ph	47 ± 2	46 ± 2	36 ± 6	58 ± 1
95	H	Me	3-Br-4-NMe2-Ph	55 ± 3	59 ± 3	34 ± 5	41 ± 1
96	H	Me	3-Br-4,5-di-OMe-Ph	16 ± 3	47 ± 1	29 ± 3	56 ± 1
97	H	Me	3-Cl-Ph	43 ± 4	54 ± 3	76 ± 4	28 ± 4
98	H	Me	3,4-di-Cl-Ph	88 ± 1	56 ± 3	71 ± 4	33 ± 4
99	H	Me	3-F-Ph	99 ± 1	76 ± 2	84 ± 2	28 ± 1
100	H	Me	2-Br-Ph	57 ± 4	100 ± 3	90 ± 1	8 ± 2
101	H	Me	4-Br-Ph	62 ± 3	92 ± 2	90 ± 1	10 ± 2
102	H	Me	Me	70 ± 4	97 ± 2	78 ± 5	5 ± 1
103	H	Me		95 ± 5	91 ± 4	89 ± 6	14 ± 2
104	H	Me		58 ± 2	100 ± 1	94 ± 2	6 ± 1
105	H	Me		82 ± 4	98 ± 3	74 ± 4	18 ± 1
106	H	Me		98 ± 2	100 ± 2	82 ± 5	6 ± 4
107	H	Me		94 ± 1	100 ± 1	92 ± 5	4 ± 2
108	H	Me		69 ± 4	96 ± 2	88 ± 9	11 ± 3
109	H	Me		84 ± 4	100 ± 3	85 ± 6	7 ± 2
110	H	Me		72 ± 6	100 ± 4	97 ± 3	11 ± 2