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Mean(+ S.E.M.) time spent in exploration during a 3 m juvenile social encounter. Prior IS resulted in a significant reduction in exploration compared to HC treated controls, p < 0.05. Systemic administration of the 5-HT2C antagonist SB 242084 45 m before the encounter dose-dependently blocked the effect of IS with 0.5 mg/kg resulting in complete reversal compared to IS-saline, p < 0.05. SB 242084 was without effect in the HC treated groups. *p<0.05 compared to HC-Saline.
