TABLE 2.
Gene | SNP | Allele | n | GPX1 activity, U/g protein | GPX3 activity, U/L | SEPP1 concentration, μg/L | MDA, μmol/L | PCC, nmol/ mg protein |
GPX1 | rs3448 | GG | 98 | 39.7 | 714 | 5.85 | 1.88 | 0.36 |
AG | 86 | 39.5 | 726 | 5.70 | 1.86 | 0.34 | ||
AA | 11 | 33.0 | 640 | 6.41 | 1.86 | 0.35 | ||
P-trend | 0.34 | 0.45 | 0.72 | 0.67 | 0.12 | |||
rs8179164 | AA | 187 | 39.0 | 716 | 5.83 | 1.86 | 0.35 | |
AT | 8 | 48.1 | 689 | 5.50 | 1.99 | 0.35 | ||
P-difference | 0.10 | 0.54 | 0.39 | 0.35 | 0.82 | |||
rs1987628 | CC | 93 | 41.7 | 713 | 5.93 | 1.86 | 0.35 | |
CT | 90 | 37.5 | 724 | 5.75 | 1.87 | 0.35 | ||
TT | 11 | 38.6 | 696 | 5.91 | 1.96 | 0.36 | ||
P-trend | 0.08 | 0.85 | 0.40 | 0.55 | 0.91 | |||
Global P | 0.02 | 0.85 | 0.66 | 0.66 | 0.33 | |||
GPX2 | rs4902347 | GG | 161 | 39.1 | 714 | 5.76 | 1.87 | 0.35 |
GA | 33 | 40.3 | 723 | 6.13 | 1.88 | 0.36 | ||
AA | 1 | 39.2 | 662 | 5.61 | 2.57 | 0.36 | ||
P-trend | 0.66 | 0.82 | 0.10 | 0.49 | 0.39 | |||
Rs17883875 | CC | 192 | 39.3 | 716 | 5.82 | 1.87 | 0.35 | |
CG | 3 | 35.4 | 675 | 5.72 | 2.00 | 0.31 | ||
P-difference | 0.62 | 0.56 | 0.86 | 0.50 | 0.21 | |||
rs4902346 | TT | 142 | 38.7 | 715 | 5.69 | 1.86 | 0.35 | |
CT | 47 | 40.5 | 713 | 6.16 | 1.87 | 0.35 | ||
CC | 6 | 47.2 | 760 | 6.37 | 2.07 | 0.37 | ||
P-trend | 0.17 | 0.67 | 0.004 | 0.43 | 0.50 | |||
rs2071566 | GG | 125 | 38.4 | 716 | 5.67 | 1.85 | 0.35 | |
GA | 59 | 40.1 | 709 | 6.03 | 1.90 | 0.35 | ||
AA | 11 | 45.8 | 740 | 6.55 | 1.97 | 0.39 | ||
P-trend | 0.14 | 0.87 | 0.002 | 0.12 | 0.34 | |||
rs10121 | CC | 171 | 39.4 | 713 | 5.76 | 1.87 | 0.35 | |
TC | 17 | 38.5 | 720 | 6.26 | 1.94 | 0.35 | ||
TT | 1 | 53.6 | 812 | 5.08 | 1.48 | 0.43 | ||
P-trend | 0.89 | 0.57 | 0.16 | 0.79 | 0.63 | |||
Global P | 0.46 | 0.70 | 0.03 | 0.67 | 0.62 | |||
GPX3 | rs3763013 | TT | 92 | 38.6 | 724 | 5.94 | 1.84 | 0.36 |
TC | 77 | 39.6 | 699 | 5.63 | 1.88 | 0.35 | ||
CC | 25 | 40.6 | 732 | 5.97 | 1.95 | 0.34 | ||
P-trend | 0.47 | 0.72 | 0.48 | 0.12 | 0.23 | |||
rs3805435 | CC | 164 | 39.3 | 721 | 5.82 | 1.87 | 0.35 | |
CT | 30 | 38.8 | 691 | 5.79 | 1.88 | 0.36 | ||
TT | 1 | 60.2 | 614 | 8.17 | 1.43 | 0.37 | ||
P-trend | 0.86 | 0.14 | 0.54 | 0.90 | 0.38 | |||
rs8177406 | TT | 138 | 38.8 | 714 | 5.83 | 1.88 | 0.35 | |
CT | 53 | 40.5 | 722 | 5.73 | 1.84 | 0.35 | ||
CC | 4 | 40.1 | 705 | 6.25 | 1.99 | 0.32 | ||
P-trend | 0.52 | 0.78 | 0.94 | 0.98 | 0.38 | |||
rs4958872 | TT | 106 | 39.9 | 734 | 5.81 | 1.86 | 0.35 | |
TC | 80 | 38.4 | 691 | 5.81 | 1.88 | 0.35 | ||
CC | 9 | 41.0 | 721 | 5.97 | 1.92 | 0.38 | ||
P-trend | 0.71 | 0.06 | 0.82 | 0.48 | 0.44 | |||
rs736775 | GG | 72 | 38.8 | 729 | 5.79 | 1.88 | 0.36 | |
AG | 94 | 39.5 | 710 | 5.80 | 1.84 | 0.35 | ||
AA | 29 | 39.9 | 700 | 5.93 | 1.95 | 0.35 | ||
P-trend | 0.69 | 0.21 | 0.62 | 0.55 | 0.60 | |||
rs3792797 | GG | 130 | 39.9 | 721 | 5.77 | 1.86 | 0.35 | |
GT | 56 | 38.0 | 702 | 5.91 | 1.92 | 0.35 | ||
TT | 3 | 38.3 | 701 | 5.58 | 1.87 | 0.41 | ||
P-trend | 0.45 | 0.33 | 0.57 | 0.29 | 0.95 | |||
Global P | 0.81 | 0.69 | 0.20 | 0.65 | 0.25 | |||
GPX4 | rs8178974 | GGGGTG/GGGGTG | 127 | 39.1 | 712 | 5.77 | 0.63 | 0.35 |
GGGGTG/- | 64 | 39.6 | 721 | 5.90 | 0.61 | 0.36 | ||
−/− | 2 | 42.9 | 722 | 6.89 | 0.70 | 0.36 | ||
P-trend | 0.67 | 0.62 | 0.25 | 0.30 | 0.28 | |||
rs4807543 | GG | 174 | 39.8 | 715 | 5.83 | 0.63 | 0.35 | |
GT | 21 | 34.9 | 719 | 5.69 | 0.63 | 0.34 | ||
P-difference | 0.11 | 0.88 | 0.56 | 0.92 | 0.54 | |||
rs8178977 | GG | 109 | 39.1 | 708 | 5.92 | 0.62 | 0.36 | |
CG | 79 | 40.2 | 718 | 5.69 | 0.64 | 0.35 | ||
CC | 7 | 34.6 | 781 | 5.69 | 0.62 | 0.33 | ||
P-trend | 0.91 | 0.22 | 0.15 | 0.33 | 0.37 | |||
rs713041 | CC | 53 | 40.2 | 711 | 5.90 | 0.62 | 0.35 | |
CT | 94 | 38.5 | 735 | 5.83 | 0.63 | 0.35 | ||
TT | 47 | 39.6 | 685 | 5.72 | 0.62 | 0.35 | ||
P-trend | 0.81 | 0.30 | 0.42 | 0.75 | 0.73 | |||
rs2074451 | GG | 53 | 39.7 | 725 | 5.89 | 0.64 | 0.36 | |
GT | 91 | 38.7 | 726 | 5.76 | 0.62 | 0.35 | ||
TT | 51 | 39.9 | 689 | 5.84 | 0.62 | 0.35 | ||
P-trend | >0.99 | 0.13 | 0.79 | 0.82 | 0.60 | |||
Global P | 0.63 | 0.82 | 0.34 | 0.43 | 0.44 | |||
SEPP1 | rs11959466 | GG | 171 | 39.1 | 720 | 5.85 | 0.63 | 0.35 |
AG | 22 | 40.5 | 688 | 5.59 | 0.60 | 0.35 | ||
AA | 1 | 37.9 | 636 | 5.39 | 0.73 | 0.32 | ||
P-trend | 0.71 | 0.17 | 0.24 | 0.73 | 0.57 | |||
rs230813 | GG | 55 | 40.9 | 725 | 5.65 | 0.66 | 0.35 | |
GC | 88 | 40.2 | 723 | 5.90 | 0.62 | 0.36 | ||
CC | 52 | 35.8 | 689 | 5.83 | 0.60 | 0.34 | ||
P-trend | 0.06 | 0.13 | 0.38 | 0.03 | 0.78 | |||
rs12055266 | AA | 111 | 38.7 | 714 | 5.82 | 0.61 | 0.35 | |
AG | 66 | 39.6 | 715 | 5.87 | 0.66 | 0.35 | ||
GG | 18 | 41.5 | 730 | 5.59 | 0.63 | 0.35 | ||
P-trend | 0.42 | 0.68 | 0.65 | 0.13 | 0.92 | |||
rs3797310 | GG | 103 | 38.8 | 713 | 5.81 | 0.60 | 0.35 | |
AG | 71 | 39.3 | 713 | 5.86 | 0.66 | 0.35 | ||
AA | 19 | 41.4 | 730 | 5.69 | 0.63 | 0.35 | ||
P-trend | 0.51 | 0.66 | 0.82 | 0.07 | 0.99 | |||
rs230819 | GG | 65 | 36.8 | 709 | 5.75 | 0.60 | 0.34 | |
GT | 81 | 40.2 | 712 | 5.92 | 0.63 | 0.36 | ||
TT | 46 | 40.5 | 730 | 5.68 | 0.67 | 0.35 | ||
P-trend | 0.14 | 0.39 | 0.83 | 0.02 | 0.50 | |||
rs13168440 | AA | 139 | 38.7 | 711 | 5.84 | 0.62 | 0.35 | |
GA | 50 | 40.2 | 727 | 5.73 | 0.64 | 0.36 | ||
GG | 4 | 50.0 | 710 | 6.40 | 0.68 | 0.35 | ||
P-trend | 0.21 | 0.50 | 0.99 | 0.28 | 0.26 | |||
rs3877899 | GG | 118 | 38.3 | 707 | 5.86 | 0.62 | 0.35 | |
GA | 61 | 41.0 | 722 | 5.70 | 0.63 | 0.36 | ||
AA | 10 | 43.1 | 745 | 5.78 | 0.69 | 0.34 | ||
P-trend | 0.16 | 0.28 | 0.44 | 0.37 | 0.58 | |||
Global P | 0.71 | 0.34 | 0.56 | 0.19 | 0.85 |
Adjusted for age, serum selenium concentrations, nonsteroid antiinflammatory drug use, smoking status, gender, and ethnicity. MDA, malondialdehyde; PCC, protein carbonyl content.