TABLE 2.

Associations between SNP in selenoenzymes and selenoenzyme activity or concentration and oxidative stress among all participants (n = 195)¹

Gene	SNP	Allele	n	GPX1 activity, U/g protein	GPX3 activity, U/L	SEPP1 concentration, μg/L	MDA, μmol/L	PCC, nmol/ mg protein
GPX1	rs3448	GG	98	39.7	714	5.85	1.88	0.36
		AG	86	39.5	726	5.70	1.86	0.34
		AA	11	33.0	640	6.41	1.86	0.35
	P-trend			0.34	0.45	0.72	0.67	0.12
	rs8179164	AA	187	39.0	716	5.83	1.86	0.35
		AT	8	48.1	689	5.50	1.99	0.35
	P-difference			0.10	0.54	0.39	0.35	0.82
	rs1987628	CC	93	41.7	713	5.93	1.86	0.35
		CT	90	37.5	724	5.75	1.87	0.35
		TT	11	38.6	696	5.91	1.96	0.36
	P-trend			0.08	0.85	0.40	0.55	0.91
Global P				0.02	0.85	0.66	0.66	0.33
GPX2	rs4902347	GG	161	39.1	714	5.76	1.87	0.35
		GA	33	40.3	723	6.13	1.88	0.36
		AA	1	39.2	662	5.61	2.57	0.36
	P-trend			0.66	0.82	0.10	0.49	0.39
	Rs17883875	CC	192	39.3	716	5.82	1.87	0.35
		CG	3	35.4	675	5.72	2.00	0.31
	P-difference			0.62	0.56	0.86	0.50	0.21
	rs4902346	TT	142	38.7	715	5.69	1.86	0.35
		CT	47	40.5	713	6.16	1.87	0.35
		CC	6	47.2	760	6.37	2.07	0.37
	P-trend			0.17	0.67	0.004	0.43	0.50
	rs2071566	GG	125	38.4	716	5.67	1.85	0.35
		GA	59	40.1	709	6.03	1.90	0.35
		AA	11	45.8	740	6.55	1.97	0.39
	P-trend			0.14	0.87	0.002	0.12	0.34
	rs10121	CC	171	39.4	713	5.76	1.87	0.35
		TC	17	38.5	720	6.26	1.94	0.35
		TT	1	53.6	812	5.08	1.48	0.43
	P-trend			0.89	0.57	0.16	0.79	0.63
Global P				0.46	0.70	0.03	0.67	0.62
GPX3	rs3763013	TT	92	38.6	724	5.94	1.84	0.36
		TC	77	39.6	699	5.63	1.88	0.35
		CC	25	40.6	732	5.97	1.95	0.34
	P-trend			0.47	0.72	0.48	0.12	0.23
	rs3805435	CC	164	39.3	721	5.82	1.87	0.35
		CT	30	38.8	691	5.79	1.88	0.36
		TT	1	60.2	614	8.17	1.43	0.37
	P-trend			0.86	0.14	0.54	0.90	0.38
	rs8177406	TT	138	38.8	714	5.83	1.88	0.35
		CT	53	40.5	722	5.73	1.84	0.35
		CC	4	40.1	705	6.25	1.99	0.32
	P-trend			0.52	0.78	0.94	0.98	0.38
	rs4958872	TT	106	39.9	734	5.81	1.86	0.35
		TC	80	38.4	691	5.81	1.88	0.35
		CC	9	41.0	721	5.97	1.92	0.38
	P-trend			0.71	0.06	0.82	0.48	0.44
	rs736775	GG	72	38.8	729	5.79	1.88	0.36
		AG	94	39.5	710	5.80	1.84	0.35
		AA	29	39.9	700	5.93	1.95	0.35
	P-trend			0.69	0.21	0.62	0.55	0.60
	rs3792797	GG	130	39.9	721	5.77	1.86	0.35
		GT	56	38.0	702	5.91	1.92	0.35
		TT	3	38.3	701	5.58	1.87	0.41
	P-trend			0.45	0.33	0.57	0.29	0.95
Global P				0.81	0.69	0.20	0.65	0.25
GPX4	rs8178974	GGGGTG/GGGGTG	127	39.1	712	5.77	0.63	0.35
		GGGGTG/-	64	39.6	721	5.90	0.61	0.36
		−/−	2	42.9	722	6.89	0.70	0.36
	P-trend			0.67	0.62	0.25	0.30	0.28
	rs4807543	GG	174	39.8	715	5.83	0.63	0.35
		GT	21	34.9	719	5.69	0.63	0.34
	P-difference			0.11	0.88	0.56	0.92	0.54
	rs8178977	GG	109	39.1	708	5.92	0.62	0.36
		CG	79	40.2	718	5.69	0.64	0.35
		CC	7	34.6	781	5.69	0.62	0.33
	P-trend			0.91	0.22	0.15	0.33	0.37
	rs713041	CC	53	40.2	711	5.90	0.62	0.35
		CT	94	38.5	735	5.83	0.63	0.35
		TT	47	39.6	685	5.72	0.62	0.35
	P-trend			0.81	0.30	0.42	0.75	0.73
	rs2074451	GG	53	39.7	725	5.89	0.64	0.36
		GT	91	38.7	726	5.76	0.62	0.35
		TT	51	39.9	689	5.84	0.62	0.35
	P-trend			>0.99	0.13	0.79	0.82	0.60
Global P				0.63	0.82	0.34	0.43	0.44
SEPP1	rs11959466	GG	171	39.1	720	5.85	0.63	0.35
		AG	22	40.5	688	5.59	0.60	0.35
		AA	1	37.9	636	5.39	0.73	0.32
	P-trend			0.71	0.17	0.24	0.73	0.57
	rs230813	GG	55	40.9	725	5.65	0.66	0.35
		GC	88	40.2	723	5.90	0.62	0.36
		CC	52	35.8	689	5.83	0.60	0.34
	P-trend			0.06	0.13	0.38	0.03	0.78
	rs12055266	AA	111	38.7	714	5.82	0.61	0.35
		AG	66	39.6	715	5.87	0.66	0.35
		GG	18	41.5	730	5.59	0.63	0.35
	P-trend			0.42	0.68	0.65	0.13	0.92
	rs3797310	GG	103	38.8	713	5.81	0.60	0.35
		AG	71	39.3	713	5.86	0.66	0.35
		AA	19	41.4	730	5.69	0.63	0.35
	P-trend			0.51	0.66	0.82	0.07	0.99
	rs230819	GG	65	36.8	709	5.75	0.60	0.34
		GT	81	40.2	712	5.92	0.63	0.36
		TT	46	40.5	730	5.68	0.67	0.35
	P-trend			0.14	0.39	0.83	0.02	0.50
	rs13168440	AA	139	38.7	711	5.84	0.62	0.35
		GA	50	40.2	727	5.73	0.64	0.36
		GG	4	50.0	710	6.40	0.68	0.35
	P-trend			0.21	0.50	0.99	0.28	0.26
	rs3877899	GG	118	38.3	707	5.86	0.62	0.35
		GA	61	41.0	722	5.70	0.63	0.36
		AA	10	43.1	745	5.78	0.69	0.34
	P-trend			0.16	0.28	0.44	0.37	0.58
Global P				0.71	0.34	0.56	0.19	0.85

¹Adjusted for age, serum selenium concentrations, nonsteroid antiinflammatory drug use, smoking status, gender, and ethnicity. MDA, malondialdehyde; PCC, protein carbonyl content.