Table 3.

Univariate and multivariate analyses of clinicopathological factors affecting CRC recurrence in all patients after liver resection for hepatic metastases.

Factors	Univariate analysis			Multivariate analysis
	n	Medium RFS months (95% CI)	p value	p value (HR, 95% CI)
Age (years)
< 65	173	10.0 (8.4-11.6)	0.103	-
≥65	106	16.9 (9.9-24.0)
Gender
Male	177	12.0 (7.7-16.3)	0.021	0.134
Female	102	11.0 (9.0-13.0)
Primary tumor
Colon	156	12.9 (8.5-17.2)	0.234	-
Rectum	123	10.0 (8.5-11.5)
Serum CEA (mg/dL)
< 200	198	12.0 (10.6-13.4)	0.567	-
≥200	72	10.0 (7.3-12.7)
Metastatic type
Synchronous	179	10.8 (9.3-12.3)	0.002	0.014
Metachronous	100	15.0 (9.1-20.9)		1.5 (1.1-2.0)
Tumor number
Solitary	181	14.0 (8.9-19.1)	0.001	0.028
Multiple	98	10.0 (7.8-8.7)		1.4 (1.0-1.9)
Maximum tumor size
< 5 cm	230	12.0 (10.0-14.0)	0.420	-
≥5 cm	49	10.0 (6.9-13.1)
Extent of liver resection
< 3 segments	202	12.0 (9.3-14.7)	0.235	-
≥3 segments	77	10.0 (7.9-12.1)
Resection margin (cm)
< 0.5	147	10.0 (8.5-11.5)	0.019	0.073
≥0.5	132	14.5 (9.1-19.9)
Histologic grade
Low grade	261	12.0 (9.3-14.7)	0.184	-
high grade	18	5.3 (1.8-8.8)

RFS, recurrence free survival; CRC, colorectal cancer; CEA, carcinoembryonic antigen; CI, confidence interval; HR, hazard ratio