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. 2012 Feb 13;7(2):e31279. doi: 10.1371/journal.pone.0031279

Figure 7. Cardiac ILK gene therapy inhibits doxorubicin-induced autophagy.

Figure 7

A, Electron micrographs showing autophagic vacuole (arrow) formation in cardiomyocyte of a doxorubicin-treated rat administered adeno-null, and lack of this in another rat administered adeno-ILK and in a control (saline-treated) rat. Scale bar, 2 µm. B, Effect of doxorubicin treatment on cardiac beclin 1 mRNA expression, and the effect of ILK treatment on this. Beclin 1 mRNA expression levels were normalized first to GAPDH and then displayed relative to levels in the control group using the2−ΔΔCt method. n = 6 per group. *P<0.05.