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. 2012 Feb 13;7(2):e31554. doi: 10.1371/journal.pone.0031554

Figure 4. Spinophilin targets PP1γ1 to CaMKIIβ.

Figure 4

A. Compressed Z-stack of confocal images of HEK293 cells expressing CaMKIIβ and GFP-tagged PP1γ1 in the absence of spinophilin. Scale bar: 10 mm B. Compressed Z-stack of confocal images of HEK293 cells expressing CaMKIIβ and GFP-PP1γ1 in the presence of spinophilin. White box shows zoomed in view of a cortical region containing all 3 proteins. Scale bar: 10 mM. C. Intensity correlation quotient showing significant co-localization of CaMKIIβ with GFP-PP1γ1 in the presence (+Spino), but not absence (−Spino), of spinophilin. Values are expressed as the mean±S.E.M from analyses of the indicated numbers of cells. ICQ values were derived from cells imaged from 2 separate sets of transfections. **P<0.01.