Table 3. Subgroup analysis of major cardiovascular events, myocardial infarction, stroke and major bleeding events after treatment with aspirin and clopidogrel agents.

		Subgroup	Intervention group	Control group	RR(95% CI)	P value	P value for heterogeneity
Major cardiovascular events	Aspirin with clopidogrel vs aspirin alone	Mean age
		>65	836/3828	929/3839	0.90 (0.83, 0.98)	0.01	0.87
		<65	1144/15418	1307/15448	0.93 (0.76, 1.13)	0.46	0.01
		Follow-up (month)
		>24	1366/11574	1497/11583	0.91 (0.85, 0.98)	0.007	0.66
		<24	614/7672	739/7704	1.07 (0.58, 1.97)	0.82	0.04
		Jadad score
		4 or 5	1418/10087	1648/10142	0.87 (0.80, 0.93)	0.0001	0.31
		<4	562/9159	588/9145	1.22 (0.63, 2.36)	0.55	0.03
	Aspirin with clopidogrel vs clopidogrel	none	445/3797	473/3802	0.94 (0.83, 1.06)	0.33	-
MI	Aspirin with clopidogrel vs aspirin alone	Mean age
		>65	94/3828	116/3839	1.24 (0.29, 5.31)	0.77	0.14
		<65	550/16471	671/16511	0.83 (0.73, 0.94)	0.002	0.35
		Follow-up (month)
		>24	236/11574	270/11583	0.87 (0.73, 1.04)	0.13	0.31
		<24	408/8725	517/8767	0.81 (0.67, 0.97)	0.03	0.30
		Jadad score
		4 or 5	488/11140	625/11205	0.78 (0.70, 0.88)	<0.0001	0.52
		<4	156/9159	162/9145	0.96 (0.77, 1.20)	0.73	0.42
	Aspirin with clopidogrel vs clopidogrel	none	73/3797	68/3802	1.07 (0.77, 1.49)	0.67	-
Stroke	Aspirin with clopidogrel vs aspirin alone	Mean age
		>65	296/3828	410/3839	0.73 (0.63, 0.84)	<0.0001	0.41
		<65	243/16471	292/16511	0.83 (0.70, 0.99)	0.03	0.39
		Follow-up (month)
		>24	446/11574	597/11583	0.75 (0.66, 0.84)	<0.0001	0.50
		<24	93/8725	105/8767	0.91 (0.62, 1.33)	0.62	0.33
		Jadad score
		4 or 5	380/11140	509/11205	0.75 (0.66, 0.85)	<0.0001	0.62
		<4	159/9159	193/9145	1.12 (0.43, 2.93)	0.81	0.09
	Aspirin with clopidogrel vs clopidogrel	none	339/3797	347/3802	0.98 (0.85, 1.13)	0.76	-
Major bleeding events	Aspirin with clopidogrel vs aspirin alone	Mean age
		>65	252/3828	162/3839	1.56 (1.29, 1.89)	<0.0001	0.68
		<65	364/15418	274/15448	1.33 (1.14, 1.56)	0.0003	0.66
		Follow-up (month)
		>24	381/11574	266/11583	1.42 (1.15, 1.75)	0.001	0.18
		<24	235/7672	170/7704	1.39 (1.14, 1.69)	0.0009	0.71
		Jadad score
		4 or 5	483/10087	331/10142	1.47 (1.28, 1.68)	<0.0001	0.62
		<4	133/9159	105/9145	1.26 (0.98, 1.63)	0.07	0.46
	Aspirin with clopidogrel vs clopidogrel	none	73/3759	22/3781	3.34 (2.08, 5.36)	<0.001	-