Figure 1. Morphology and histology of the testes in 4-week-old 129.MOLF-L1 male mice irradiated in utero with two doses of 0.8 Gy and controls.

Testicular morphology showing bilateral (A) and unilateral (B) TGCTs from irradiated mice. Note that the testis without TGCT after in utero radiation exposure (B) is smaller than the normal untreated testis from a 4-week-old mouse (insert in B). Testis sections showing teratoma containing tissues apparently from multiple dermal origins identified by morphology (C), and TGCT containing only neuroepithelial cells (NE) (D). CA: cartilage; BM: bone marrow; MS: muscle, EEP: endodermal epithelium. ST: seminiferous tubule; BV: blood vessel. Sections from testes of 4-week old irradiated (E) and contol (F) mice without TGCT showing qualitatively normal spermatogenesis. Bar: 0.5 cm in A & B, and 50 µm in C–F.