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. 2012 Feb 13;7(2):e31731. doi: 10.1371/journal.pone.0031731

Figure 1. The effects of chronic exposure to WIN55,212-2 during late-adolescence on hippocampal and non-hippocampal dependent tasks.

Figure 1

1a. Rats tested in the water maze 24 h, but not 10 d, after the last WIN injection, show increased latency to locate the hidden platform compared with the vehicle group on the first training day (Acq1–7). (*, p<0.05: WIN 24 h different from Vehicle 24 h). Inset: a control experiment where rats were tested in the water maze 24 hours following a single WIN injection. 1b. Rats tested in the object location task 24 h, 10 d, 30 d and 75 d after the last vehicle injection spent significantly more time exploring the new location compared with the WIN groups. (*, p<0.05; **, p<0.01: Vehicle different from WIN). On the right square: a control experiment where rats were tested in the object location task 24 hours following a single WIN injection. 1c. Rats tested in the object recognition task 24 h or 10 d, but not 30 d, after the last vehicle injection spent significantly more time exploring the new location compared with the WIN groups (*, p<0.05; ***, p<0.001: Vehicle different from WIN). On the right square: a control experiment where rats were tested in the object recognition task 24 hours following a single WIN injection.