Table 1. Summary of results.
Time Point | |||
Test | 24 hours | 10 days | 30 days |
Water maze | Impairment in acquisition | No effect | - |
Location recognition | Impairment in short-term memory | Impairment in short-term memory | Impairment in short-term memory (also at 75 days) |
Object recognition | Impairment in short-term memory | Attenuation of short-term memory | No effect |
Synaptic plasticity – PP-DG | No effect | No effect | No effect |
Synaptic plasticity – vSub-NAc | Impairment of LTP | Impairment of LTP | No effect |
Open field | Increased time in the center | No effect | No effect |
Sucrose consumption | No effect | No effect | No effect |
Weight | No effect | No effect | No effect |
The table summarizes the effects of chronic i.p. treatment with the CB1/CB2 receptor agonist WIN55,212-2 (1.2 mg/kg) for two weeks during the late adolescence period (post-natal days 45–60) on behavioral and electrophysiological measures of cognitive performance tested 24 hrs, 10 and 30 days after the last drug injection.