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. 2012 Feb 13;7(2):e31731. doi: 10.1371/journal.pone.0031731

Table 1. Summary of results.

Time Point
Test 24 hours 10 days 30 days
Water maze Impairment in acquisition No effect -
Location recognition Impairment in short-term memory Impairment in short-term memory Impairment in short-term memory (also at 75 days)
Object recognition Impairment in short-term memory Attenuation of short-term memory No effect
Synaptic plasticity – PP-DG No effect No effect No effect
Synaptic plasticity – vSub-NAc Impairment of LTP Impairment of LTP No effect
Open field Increased time in the center No effect No effect
Sucrose consumption No effect No effect No effect
Weight No effect No effect No effect

The table summarizes the effects of chronic i.p. treatment with the CB1/CB2 receptor agonist WIN55,212-2 (1.2 mg/kg) for two weeks during the late adolescence period (post-natal days 45–60) on behavioral and electrophysiological measures of cognitive performance tested 24 hrs, 10 and 30 days after the last drug injection.