Table 2.

Effect parameters

Primary effect parameter	Secondary effect parameters	Tertiary effect parameters
Major Depression Inventory	Anxiety measured by Visual Analogue Scale (VAS) Total sleep time, sleep efficiency, sleep latency and periods awake measured by actigraphy Changes in cognitive function measured by a neuropsychological test battery PER3 genotype correlated with sleep, cognitive function and depressive symptoms	Fatigue, pain, well-being and sleep quality/quantity measured by VAS Sleep diary Sleepiness measured by the Karolinska Sleepiness Scale