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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Neuropharmacology. 2012 Jan 2;62(5-6):1935–1943. doi: 10.1016/j.neuropharm.2011.12.026

Figure 3.

Figure 3

Onset of desensitization to 300 nM nicotine. Panel a shows data for [3H]-GABA release from cortex for WT and α5KO mice stimulated by 10 μM ACh for 20s (WT, n=5 experiments; α5KO, n=6) or by 20 mM K+ for 20s (WT, n=4; α5KO n=3). Panel b presents data for [3H]-DA release from striatum for α6 KO mice and for α5KO mice in the presence of α-CtxMII (50 nM) using the same stimulations as for Panel a (all, n=3). Panel c shows data for [3H]-DA release from striatum for α6 KO mice using the same stimulations as for Panel a (n=8 for ACh; n=3 for K+).