Table 1.

Onset parameters for 300 nM nicotine desensitization

Subtype assayed	Genotype/ Antagonist	Region	Assay	Half-time (τ) of onset (min)a	% desensitization by 300 nM nic
(α4β2)2β2	α5KO	Cortex	GABA	0.39 ± 0.04	56 ± 4
(α4β2)2β2	α5KO/αCtxMII	Striatum	DA	0.32 ± 0.03	60 ± 4
(α4β2)2β2 + (α4β2)2α5	WT	Cortex	GABA	0.17 ± 0.06	48 ± 6
(α4β2)2β2 + (α4β2)2α5	α6KO	Striatum	DA	0.18 ± 0.05	48 ± 11
(α6β2)2β3	α4KO	Striatum	DA	0.052 ± 0.008	25 ± 1

^aHalf-times of onset should be considered estimates.