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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Neuropharmacology. 2012 Jan 2;62(5-6):1935–1943. doi: 10.1016/j.neuropharm.2011.12.026

Table 2.

Recovery parameters for 300 nM nicotine desensitization

Subtype
assayed		 Genotype/
Antagonist		 Region Assay Half-time (τ) of
recovery (min)		 Starting
% desensitization
(α4β2)2β2 α5KO Cortex GABA 8.8 ± 0.9 76 ± 10
(α4β2)2β2 α5KO/αCtxMII Striatum DA 5.8 ± 0.5 59 ± 5
(α4β2)2β2 +
(α4β2)2α5		 WT Cortex GABA 2.4 ± 0.4 54 ± 6
(α4β2)2β2 +
(α4β2)2α5		 α6KO Striatum DA 1.1 ± 0.2 64 ± 8
(α6β2)2β3 α4KO Striatum DA 6.8 ± 3.3 27 ± 16