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DC50 values for 10 min nicotine desensitization
| Subtype assayed |
Genotype/ Antagonist |
Region | Assay | nicotine DC50 (nM) |
Max % desensitization |
|---|---|---|---|---|---|
| (α4β2)2β2 | α5KO | Cortex | GABA | 9 ± 4 | 53 ± 9 |
| (α4β2)2β2 | WT | Thalamus | GABA | 11 ± 4 | 65 ± 9 |
| (α4β2)2β2 | α5KO + αCtxMII |
Striatum | DA | 8 ± 2 | 44 ± 4 |
| (α4β2)2β2 + (α4β2)2α5 |
WT | Cortex | GABA | 71 ± 17 | 63 ± 8 |
| (α4β2)2β2 + (α4β2)2α5 |
α6KO | Striatum | DA | 117 ± 12 | 77 ± 4 |
| (α6β2)2β3 | α4KO | Striatum | DA | 22 ± 11 | 38 ± 9 |
