Figure 5. The MEK inhibitor U0126 significantly blocks ATP-induced increases in basal cell proliferation.
The MEK inhibitor U0126 (400 nmoles/kg) was intranasally instilled 1 hour prior to ATP treatment (400 nmoles/kg) and tissue was collected 48 hours post-instillation of ATP. Quantification of PCNA+ cells in the basal layer of the OE were from 9 sections of 3 mice/group. * indicates a significant difference from vehicle-vehicle at p < 0.01. # indicates a significant difference from vehicle-ATP at p < 0.05 (two-way ANOVA followed by Newman-Keuls post hoc test).