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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Mol Cell Neurosci. 2011 Nov 30;49(2):158–170. doi: 10.1016/j.mcn.2011.11.004

Figure 6. NPY Y1 receptor antagonist BIBP3226 significantly blocks ATP-induced activation of p44/42 ERK in mouse OE.

Figure 6

Mice were intranasally instilled with ATP (400 nmoles/kg) followed by BIBP3226 instillation (20 nmoles/kg) 5 min later. Tissue was collected 1 hour post-instillation of ATP. (A) Representative immunoblots for phospho-p44/42 ERK and p44/42 ERK. (B–C) Quantification of phospho-p42 ERK and phospho-p44 ERK (n = 4 mice/group). The levels of phospho-p44/42 ERK were normalized to p44/42 ERK and data are expressed as ratios to vehicle-vehicle animals. * indicates significant differences from vehicle-vehicle at p < 0.05. # indicates significant differences from ATP-vehicle at p < 0.05 (two-way ANOVA followed by Newman-Keuls post hoc test).