Table 1.

Proportional hazards regression model showing risk of disease recurrence and progression by fluorescence in situ hybridization (FISH) assay results at various times^*

Time and assay result	No. at risk	No. with Recurrence/Progression	Hazard ratio	95% confidence interval	p value
Risk of recurrence
Baseline FISH
Negative	45	8
Positive	81	31	2.19	(1.01-4.77)	0.042
FISH at 6 weeks
Negative	74	13
Positive	50	25	3.04	(1.55-5.95)	0.001
FISH at 3 months
Negative	59	9
Positive	48	18	4.95	(2.33-10.50)	<0.001
FISH at 6 months
Negative	59	10
Positive	26	18	5.02	(2.31-10.90)	<0.001
Risk of progression
Baseline FISH
Negative	45	2
Positive	81	16	4.53	(1.04-19.70)	0.027
FISH at 6 weeks
Negative	74	3
Positive	50	15	8.00	(2.32-27.67)	<0.001
FISH at 3 months
Negative	59	4
Positive	48	8	4.94	(1.59-15.37)	0.002
FISH at 6 months
Negative	59	2
Positive	26	8	12.63	(2.67-59.78)	<0.001

^*Totals at each time include only those patients “at risk” at that time; hence n = 126 only for the baseline FISH data.