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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Vet Comp Oncol. 2011 May 18;10(1):44–56. doi: 10.1111/j.1476-5829.2011.00274.x

Figure 2. Synergistic enhancement of MH cell killing by combinations of bisphosphonates with vincristine or doxorubicin.

Figure 2

Significant killing of MH cells was seen in A-D when bisphosphonates were combined with chemotherapy as determined via MTT assay (A), DH82 MH cells were either untreated (CTRL) or treated with clodronate (Clod) or vincristine (Vinc) or both in combination (Clod + Vinc) for 72 hours. In (B), the interaction between zoledronate (Zol) and doxorubicin (Dox) was assessed. Similar experiments were done in (C) for the combination of pamidronate (Pam) with doxorubicin and in (D) for the combination of alendronate (Alen) and doxorubicin. (* = p < 0.05).