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The dock-and-coalesce mechanism for the association of IDPs that form extended interaction surfaces with their targets. In the first sub-step (with rate constant k1+), a segment of the IDP makes the disorder-to-order transition and docks to its cognate sub-site. This docked segment can either dissociate (with rate constant k1−), or allows the remaining segment to coalesce around its sub-site (with rate constant k2+), resulting in the native complex.
