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. Author manuscript; available in PMC: 2013 Feb 21.
Published in final edited form as: Vaccine. 2011 Dec 15;30(9):1737–1745. doi: 10.1016/j.vaccine.2011.12.026

Fig. 4. Vaccine-elicited antibody responses.

Fig. 4

(A) Estimated titers of binding Ab for the SIV239 and SIVE660 Envs. (B) Avidity indices of the elicited Env specific Ab for the SIV239 and SIVE660 Envs. (C) Neutralizing titers of the elicited sera for tier 1 viruses. E660.11 and E660.17 are molecularly cloned Envs from the genetically complex challenge stock. SIVE660/CG7G is a molecular clone of a recent transmission [43]. 7312A/V33M is a HIV-2 virus mutated to test for the presence of neutralizing Ab for the CD4i site [27]. (D) ADCC activity of the elicited sera for SIV2339 gp120 coated CEM.NKRCCR5 cells. (E) and (F) Env and Gag specific IgA in rectal secretions at different times in the trial. The DDMM group is depicted in turquoise and the MMM group, in fuchsia. The number of Ds and Ms indicate the number of immunizations. Wk 37 is a memory time point. The grey boxes in (C) – (F) represent the level below which responses are not considered significant. * is used to indicate p<0.05; **, p<0.01; and ***, p<0.001.